Adult Hodgkin’s Lymphoma
Adult Hodgkin’s Lymphoma
Hodgkins Lymphoma or Hodgkins Disease (two terms for the same thing) is a malignant (cancerous) growth of cells in the lymph system. Hodgkins Disease is the better known form of lymphoma (the other lymphomas are grouped into what is called the Non-Hodgkins Lymphomas).
The incidence or number of cases of Hodgkins lymphoma (about 7880 cases, 4330 men and 3550 women in the United States this year) is significant although less than the number of cases of Non-Hodgkins lymphoma (over 53,000 in the US this year). More on Hodgkins incidence.
Hodgkins has a long and rich history. The disease was named after Thomas Hodgkin (1798-1866), a English scholar and Quaker physician working at Guys Hospital in England. Lymphatic disease was first described in 1666 by Malpighi although it was in Hodgkins 1832 paper On Some Morbid Appearances of the Absorbent Glands and Spleen that cases of Hodgkins lymphoma were well documented. Hodgkins name was attached to the disease in 1865 in a paper by Wilks.
What now differentiates Hodgkins lymphoma is the presence of Reed-Sternberg cells (and variations on this cell) in the cancerous area, a cell specific to Hodgkins Disease. There is definitive evidence that the the cancerous cells are of B-cell lymphocyte (white blood cell) origin. The Epstein-Barr virus (EBV) also appears to be a factor, at least in some cases – appearing in about 40-50% of Hodgkins cases. Hodgkins may be more prevalent in people who have contracted infectious mononucleosis. Also there are links between Hodgkins