Methadone
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German scientists Max BockmĂ‘Ĺ’hl and Gustav Ehrhart first synthesized methadone in 1937. The synthetic opioid analgesic was created while they were searching for a pain reliever that would be safe to use during surgeries and had a low potential for addiction. On September 11, 1941, they filed for a patent for what they called Hoechst 10820 or Polamidon. Eli Lilly and Company brought methadone to the United Stated in 1947. They gave it the trade name Dolophine, which came from the German Dolphium, which came from the Latin “dolor” for pain (Wikipedia).
Methadone is mainly used to treat addiction to narcotics, but may also be used to manage chronic pain. Methadone was not used to treat heroin addiction until the mid 1960s. Drs. Vincent Dole and Marie Nyswanders experiments showed that the craving for heroin was blocked by methadone. Methadone acts on the opioid receptors and creates some of the same effects as morphine or heroin. While the user does not get high, methadone keeps them from suffering the effects of withdrawal (Wikipedia). Methadone is usually taken orally, either by mixing liquid or powdered methadone with orange juice or Tang; or in pill form. Methadone can also be taken in an IV (Simpson 30). The human body metabolizes methadone slowly; it has a half-life of twenty-four to forty-eight hours. This means that methadone only has to be administered once a day to patients (Wikipedia). Heroin addicts can then have a normal life, because they are no longer high all the time and do not suffer from withdrawal. The only problem is that methadone is even more addictive than heroin. Users who abruptly stop using methadone will still suffer from withdrawal, but less severely (Simpson 13-15).
People have argued that methadone treatment does not help the drug problem. It only switches their addiction from one drug to another. Morphine does the exact same thing methadone does, but without the addicting properties. However, methadone only costs around twenty U.S. dollars for a months supply. The same months supply of Demerol or morphine would cost six times that. Also, methadone advocates have argued that methadone treatment stops heroin addicts from buying illegal drugs on the street and using dirty needles that may transmit HIV or AIDS (Simpson 32).
Methadones chemical structure is C21H27NO.

Heroin addicts who try to quit eventually relapse eighty percent of the time. Methadone provides a safe alternative to going “cold turkey” (Simpson 28-29). A study by the National Instituted on Drug Abuse (NIDA) found that patients treated with methadone decreased heroin usage 69%, cocaine usage by 48%, and increased full time work by users by 24% (EBSCOhost).
Methadone can be bought on the street, although it is not common. Addicts unable to get into legal methadone programs fuel the demand for this. Most of the methadone found on the street comes from pain killer prescriptions of methadone and theft from factories and shippers. Methadone can be known on the street at dollies, amidone, and fizzies.
Methadone has many of the same side effects as other opioids. These include an allergic reaction that causes difficulty breathing; closing of the throat; swelling of the lips, tongue, or face; or hives. Hallucinations, chest pain, fainting spells, and loss of consciousness can also be some of the more severe side effects. Less serious side effects of methadone include anxiety, dizziness, nausea, diarrhea, drowsiness, decreases appetite, dry mouth, constipation, and muscle weakness. Methadone has also been found to cause womens menstrual periods to become irregular (Drug).
It is not recommended that methadone be taken with any other drugs unless the user is cleared by their doctor to do so. Drugs that may react with methadone include monoamine oxidase inhibitors; phenelzine; tranylcypromine; rifampin; narcotic pain relievers such as codeine, hydrocodone, morphine, and oxycodone.