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Schizophrenia Schizophrenia December 10, 2007 According to the American Psychiatric Association’s “Guide for the Treatment of Patients with Schizophrenia” antipsychotic medications are indicated for nearly all acute psychotic episodes in patients with schizophrenia. Schizophrenia is defined as a chronic, severe, and disabling brain disease. Approximately 1% of the population develops schizophrenia. More than 2 million.