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Hemoglobinopathies Introduction Hemoglobinopathies is the medical term for a group ofblood disorders and diseases that affect the red blood cells resulting in abnormal hemoglobin. Hemoglobinopathies are inherited, lifelong blood disorders that include sickle cell disease (SCD) and thalassemia.Thalassemia affects the ability of the red blood cells to produce a normal amount of hemoglobin, leading to.