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Pheochromocytoma Cancer Pheochromocytoma Cancer Definition of Pheochromocytoma: The tumor forms in the center of the adrenal gland (gland located above the kidney) and causes it to make too much adrenaline. Pheochromocytoma cancer is usually benign (which is the opposite of malignant) but can cause high blood pressure, pounding headaches, heart palpitations, flushing of the face,.