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Depleted Uranium – Hazardous Chemical Depleted Uranium – Hazardous Chemical Depleted Uranium- Hazardous Chemical Depleted uranium is a byproduct of the industrial processes that produce enriched uranium, which is used in nuclear reactors and nuclear weapons. Natural uranium consists of three isotopes or forms of the uranium atom: uranium 234 (U-234), uranium 235 (U-235), and uranium 238 (U-238)..