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Detailed Differences Between Eukaryotic and Prokaryotic Cells Detailed Differences Between Eukaryotic and Prokaryotic Cells DETAILED DIFFERENCES BETWEEN EUKARYOTIC AND PROKARYOTIC CELLS Cells are divided into two categories namely the Prokaryotes and Eukaryotes. These two have varying differences between them. Speaking in simple cell biology words, prokaryotes are primitive, simple organisms that lack membranous cell organelles..