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Influenza Virus Structure Influenza virus structureInfluenza viruses are roughly spherical, although somewhat pleomorphic, particles, ranging from 80 to 120 nm in diameter. 1, 7 Figure 5presents a model of the overall structure of the influenza virus. A characteristic feature of influenza virus particles is their external layer ofapproximately 500 spike-like projections. These spikes represent the envelope glycoproteins HA.