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Mediates Glioblastoma Cell Proliferation Through the Akt and Mtor Signaling Pathways Essay Preview: Mediates Glioblastoma Cell Proliferation Through the Akt and Mtor Signaling Pathways Report this essay The goal of the study is to show that phorbol 12-myristate-13-acetate (PMA) stimulated activation of protein kinase C-Д§ (PKC-Д§) in U-251 glioblastoma (GBM) cells resulted in activation of.