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Risk of Cardiovascular Events with Rofecoxib Essay Preview: Risk of Cardiovascular Events with Rofecoxib Report this essay Risk of Cardiovascular Events with Rofecoxib Abstract Rofecoxib causes cardiotoxicity through the suppression of prostaglandin I2 – an anti-clotting agent in blood. Rofecoxib use is associated with an increase in risk of myocardial infarction, ischemic stroke and also.