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How one Protein Can Kill: An Examination of Harlequin IchthyosisEssay Preview: How one Protein Can Kill: An Examination of Harlequin IchthyosisReport this essayHow One Protein Can Kill:An Examination of Harlequin IchthyosisAn infant born with harlequin ichthyosis (HI) is phenotypically distinguished by a covering of thick scales with deep, red fissuring. Most neonates with this congenital.