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A Questionable Drug: Depo Provera A Questionable Drug: Depo Provera A Questionable Drug: Depo Provera For decades, Depo Provera has been used around the world, not always for the same purpose. The drug, medroxyprogesterone acetate, more commonly known as Depo Provera, was originally made to be an injectable form of long-term birth control. When Depo.