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What Is Diphtheria? Essay Preview: What Is Diphtheria? Report this essay Diphtheria Definition What is diphtheria? Diphtheria is an infectious disease caused by the bacteriumCorynebacterium diphtheriae. This disease primarily affects the mucous membranes of the respiratory tract (respiratory diphtheria), although it may also affect the skin (cutaneous diphtheria) and lining tissues in the ear, eye,.