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Compare and Contrast the Overall Cell Structure of Prokaryotes and Eukaryotes Essay Preview: Compare and Contrast the Overall Cell Structure of Prokaryotes and Eukaryotes Report this essay Chapter 4 Study GuideCompare and contrast the overall cell structure of prokaryotes and eukaryotes.Prokaryote: “prenucleus”Eukaryote: “true nucleus”One circular chromosome, not in a membraneNo histonesNo membrane enclosed organellesPeptidoglycan cell walls (if.