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Serotonin Essay Preview: Serotonin Report this essay Serotonin Chemical Nature/Structure: Serotonin (5-hydroxytryptamine, or 5-HT) is a monoamine neurotransmitter synthesized in serotonergic neurons in the central nervous system (CNS) and enterochromaffin cells in the gastrointestinal tract. The neurons in the brain that release serotonin are found in small dense collections of neurons called Raphe Nuclei. The.