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Acromegaly Essay title: Acromegaly The foundations of the Endocrine System consist of hormones and glands. These glands are ductless and their secretions are sent through the bloodstream. Endocrine glands also control bodily metabolic activity. The major glands that make up the human endocrine system are the hypothalamus, pituitary, thyroid, parathyroids, adrenals, pineal body, the pancreas,.