Pharmacology I Review – Study Guide – SuzanaG
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Pharmacology I Review
Lauren Busse Pharmacology 1 Final Review Schedule for Controlled Substances Schedule 1 • High abuse potential • Not legally approvedSchedule 2 • As above with accepted useSchedule 3 • Lower abuse potentialSchedule IV • Still lower abuseSchedule V • Contain only small amount of narcotic • Minimal risk for abuse* If wasting part of the narcotic, another nurse must witness the disposal of the medication. You dispose of a narcotic in the trashcan*6 rights of Drug Administration • Right client • Right medication • Right dose • Right time • Right route • Right documentation* Always assess for allergies before administering a medication** Always administer a medication and then document!!*Pharmacokinetics: what the body does to the drug4 major processes • Absorption: how it gets in the body; the rate at which a drug leaves its site of administration and becomes bioavailable • Distribution: how it gets around the body; process by which drug is carried from its site of absorption to its site of action • Metabolism: how it’s broken down in the body (LIVER); process by which the body changes a drug from its original form to a form that is pharmacologically inactive and can be readily eliminated or excreted. A.K.A biotransformation • First-pass effect: metabolism of a drug & its passage from liver into systemic circulation • Drugs given parenterally bypass the first pass-effect
• Excretion: how you get rid of the drug (kidneys, lungs, sweat, breath); process where all drugs and/or their metabolites are eliminated from the bodyPharmacodynamics: what the drug does to the bodyHalf-life: time required to reduce by ½ the amount of drug concentration in the body; a measure of the rate at which the drug is eliminated Antineoplastic Agents Cell cycle non-specific- cytotoxic in any phase • Alkylating agents • Cytotoxic antibiotics Cell cycle specific- cytotoxic in any phase • Antimetabolites • Natural products • Hormonal agents Chemotherapy: harmful to all rapidly growing cells • Affects cancer cells plus normal human cells: hair follicles, GI cells, bone marrow cells • Absorbed through skin or mucous membranes by: injection, ingestion, and inhalation • Dose-limiting side effects due to high risk for toxicity • Wear gown, gloves, & mask/eyewear Extravasation: leaking of an antineoplastic drug into surrounding tissues during IV administration. Continuous monitoring of IV site is essential. • If suspected, STOP IV SITE • Aspirate remaining drug of blood from the tube • DO NOT REMOVE IV LINE- may need to give antidote through existing IV tube. Some antidotes not given through IV catheter • Cover are with sterile, occlusive dressing • Apply warm or cold compresses • Elevate the limb • Follow extravasation instructions per facility protocolNursing Implications • Assess baseline blood counts before giving any antineoplastic agents
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By: SuzanaG
Submitted: March 20, 2017
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