Cmmb Notes
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05-09-13
CMMB 511
No final exam
Journal based course.
Try to think of everything in terms of GENE EXPRESSION
Biol questions
concepts
strategies and approaches – need cross f(x) or complimentary approaches to develop a compreshensive understanding
techniques – lots of techniques, make sure using appropriate techniques
outcome of results
overall conclusions
DNA content per haploid genome:
Bacteria: 2 x 106 bp
Mammal: 2 x 109 bp
Complexity of the genomes. Important question in biol scinces is
How is the genome organized?
How is gene expression regulated? Very tightly regulated, don’t expect genes to go up or doen. Different mechanisms, remarkable complexity.
These are important questions in the understanding of cellular processes including:
cell differentiation, development, diseases (etc). the study of processes comes down to the two above questions. If you know the basic concepts, can answer anything!
05-09-15
How is the genome organized?
How do we know the presence of the sequences. Will re-visit classic methods to determine the sequence of these genomes.
S(X) of the chromo
Each chromo is a single, linear DNA molecule
At the